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  • Steven Moffat:

    *enters a room, takes something out of his pocket and conspicuously places it in the room*

  • Fans:

    What did you just take out of your pocket?

  • Moffat:

    What? Nothing. Oh, you mean that? Well, that's BEEN HERE THE WHOLE TIME.

  • Fans:

    ...No it hasn't.

  • Moffat:

    I assure you it has. It's been there for almost fifty years.

  • Fans:

    Nope, we have never seen that before. We just watched you take it out of your pocket and put it down.

  • Moffat:

    *reaches into his pocket again, pulls out John Hurt*

  • Fans:

    What-what're you...YOU'RE DOING IT AGAIN, LOOK, RIGHT NOW.

  • Moffat:

    NO NO THAT HAS DEFINITELY BEEN THERE FOR AT LEAST TEN YEARS MAYBE MORE

scinerds: Scientists Report First Success in Cloning Human Stem Cells It’s been 17 years since Dolly the sheep was cloned from a mammary cell. And now scientists applied the same technique to make the first embryonic stem cell lines from human skin cells. Ever since Ian Wilmut, an unassuming embryologist working at the Roslin Institute just outside of Edinburgh stunned the world by cloning the first mammal, Dolly, scientists have been asking – could humans be cloned in the same way? Putting aside the ethical challenges the question raised, the query turned out to involve more wishful thinking than scientific success. Despite the fact that dozens of other species have been cloned using the technique, called nuclear transfer, human cells have remained stubbornly resistant to the process. Until now. Shoukhrat Mitalipov, a professor at Oregon Health & Science University and his colleagues report in the journal Cell that they have successfully reprogrammed human skin cells back to their embryonic state. The purpose of the study, however, was not to generate human clones but to produce lines of embryonic stem cells. These can develop into muscle, nerve, or other cells that make up the body’s tissues. The process, he says, took only a few months, a surprisingly short period to reach such an important milestone. Nuclear transfer involves inserting a fully developed cell – in Mitalipov’s study, the cells came from the skin of fetuses – into the nucleus of an egg, and then manipulating the egg to start dividing, a process that normally only occurs after it has been fertilized by a sperm. After several days, the ball of cells that results contains a blanket of embryonic stem cells endowed with the genetic material of the donor skin cell, which have the ability to generate every cell type from that donor. In Dolly’s case, those cells were allowed to continue developing into an embryo that was then transferred to a ewe to produce a cloned sheep. But Mitalipov says his process with the human cells isn’t designed to generate a human clone, but rather just to create the embryonic stem cells. These could then be manipulated to create heart, nerve or other cells that can repair or treat disease. “I think this is a really important advance,” says Dieter Egli, an investigator at the New York Stem Cell Foundation. “I have a very high confidence that versions of this technique will work very well; it’s something that the field has been waiting for.” Egli is among the handful of scientists who have been working to perfect the technique with human cells and in 2011, succeeded in producing human stem cells, but with double the number of chromosomes. In 2004, Woo Suk Hwang, a veterinary scientist at Seoul National University, claimed to have succeeded in achieving the feat, but later admitted to faking the data. Instead of generating embryonic stem cell lines via nuclear transfer, Hwang’s group produced the stem cells from days-old embryos, a technique that had already been established by James Thomson at University of Wisconsin in 1998. Full Article
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scinerds:

Scientists Report First Success in Cloning Human Stem Cells

It’s been 17 years since Dolly the sheep was cloned from a mammary cell. And now scientists applied the same technique to make the first embryonic stem cell lines from human skin cells.

Ever since Ian Wilmut, an unassuming embryologist working at the Roslin Institute just outside of Edinburgh stunned the world by cloning the first mammal, Dolly, scientists have been asking – could humans be cloned in the same way? Putting aside the ethical challenges the question raised, the query turned out to involve more wishful thinking than scientific success. Despite the fact that dozens of other species have been cloned using the technique, called nuclear transfer, human cells have remained stubbornly resistant to the process.

Until now. Shoukhrat Mitalipov, a professor at Oregon Health & Science University and his colleagues report in the journal Cell that they have successfully reprogrammed human skin cells back to their embryonic state. The purpose of the study, however, was not to generate human clones but to produce lines of embryonic stem cells. These can develop into muscle, nerve, or other cells that make up the body’s tissues. The process, he says, took only a few months, a surprisingly short period to reach such an important milestone.

Nuclear transfer involves inserting a fully developed cell – in Mitalipov’s study, the cells came from the skin of fetuses – into the nucleus of an egg, and then manipulating the egg to start dividing, a process that normally only occurs after it has been fertilized by a sperm. After several days, the ball of cells that results contains a blanket of embryonic stem cells endowed with the genetic material of the donor skin cell, which have the ability to generate every cell type from that donor. In Dolly’s case, those cells were allowed to continue developing into an embryo that was then transferred to a ewe to produce a cloned sheep. But Mitalipov says his process with the human cells isn’t designed to generate a human clone, but rather just to create the embryonic stem cells. These could then be manipulated to create heart, nerve or other cells that can repair or treat disease.

“I think this is a really important advance,” says Dieter Egli, an investigator at the New York Stem Cell Foundation. “I have a very high confidence that versions of this technique will work very well; it’s something that the field has been waiting for.” Egli is among the handful of scientists who have been working to perfect the technique with human cells and in 2011, succeeded in producing human stem cells, but with double the number of chromosomes. In 2004, Woo Suk Hwang, a veterinary scientist at Seoul National University, claimed to have succeeded in achieving the feat, but later admitted to faking the data. Instead of generating embryonic stem cell lines via nuclear transfer, Hwang’s group produced the stem cells from days-old embryos, a technique that had already been established by James Thomson at University of Wisconsin in 1998.

Full Article

science-junkie: A storage power plant on the seabed Norwegian research scientists will contribute to realising the concept of storing electricity at the bottom of the sea. The energy will be stored with the help of high water pressure.The idea of an underwater pumped hydroelectric power plant may sound like Jules Verne fiction, but then it was hatched by a German engineer who has spent much of his professional life working in aerospace technology.“Imagine opening a hatch in a submarine under water. The water will flow into the submarine with enormous force. It is precisely this energy potential we want to utilize,” explains Rainer Schramm, inventor and founder of the company Subhydro AS to Gemini.no. “Many people have launched the idea of storing energy by exploiting the pressure at the seabed, but we are the first in the world to apply a specific patent-pending technology to make this possible,” he adds.Read more
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science-junkie:

A storage power plant on the seabed

Norwegian research scientists will contribute to realising the concept of storing electricity at the bottom of the sea. The energy will be stored with the help of high water pressure.

The idea of an underwater pumped hydroelectric power plant may sound like Jules Verne fiction, but then it was hatched by a German engineer who has spent much of his professional life working in aerospace technology.

“Imagine opening a hatch in a submarine under water. The water will flow into the submarine with enormous force. It is precisely this energy potential we want to utilize,” explains Rainer Schramm, inventor and founder of the company Subhydro AS to Gemini.no. “Many people have launched the idea of storing energy by exploiting the pressure at the seabed, but we are the first in the world to apply a specific patent-pending technology to make this possible,” he adds.

Read more

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